Scope of Review: This article reviews studies demonstrating that there is indeed mitochondrial dysfunction in islets in T2D, and that GWAS have identified a variant in the gene encoding transcription factor B1 mitochondrial ( TFB1M ), predisposing to T2D due to mitochondrial dysfunction and impaired insulin secretion. Mechanistic studies of the nature of this pathogenetic link, as well as of other mitochondrial transcription factors, are described. Major Conclusions: Based on this, it is argued that transcription and translation in mitochondria are critical processes determining mitochondrial function in β-cells in health and disease.
The NFL and Jerry Jones don’t care if Elliott really did beat up Thompson, or if he didn’t, or if maybe it’s a complicated situation, or if maybe it isn’t. They care, as they have always cared, about getting the right PR spin on it so that nobody will feel bad about forking over thousands of dollars to visit Cowboys stadium and watch Elliott run. While they’re at it, they’d like to use concerns about domestic-violence victims to gain more power to enforce a personal-conduct policy that is so arbitrary it doles out longer suspension for marijuana than for beating your partner—while, apparently, working with America’s district attorneys. This is what “ getting it right ” looks like with the NFL—an arbitrary power grab that helps nobody except the likes of Jones, the billionaire who just wants to keep on making more billions.